• Aspirin as secondary prevention in colorectal cancer liver metastasis (ASAC trial): study protocol for a multicentre randomized placebo-controlled trial 

      Yaqub, Sheraz; Bjørnbeth, Bjørn Atle; Angelsen, Jon-Helge; Fristrup, Claus W.; Grønbech, Jon Erik; Hemmingsson, Oskar; Isaksson, Bengt; Juel, Ingebjørg Soterud; Larsen, Peter Nørgaard; Lindell, Gert; Mortensen, Frank V.; Mortensen, Kim Erlend; Rizell, Magnus; Sandström, Per; Sandvik, Oddvar Mathias; Sparrelid, Ernesto; Taflin, Helena; Taskén, Kjetil; Brudvik, Kristoffer Watten; Fretland, Åsmund Avdem; Horn, Arild; Kleive, Dyre; Labori, Knut Jørgen; Lassen, Kristoffer; Røsok, Bård Ingvald; Søreide, Jon Arne; Tholfsen, Tore; Villanger, Olaug; Waage, Anne (Journal article; Tidsskriftartikkel, 2021-09-20)
      Background: Colorectal cancer is one the most common cancers in the western world with increasing incidence. Approximately 50% of the patients develop liver metastases. Resection of liver metastases is the treatment of choice although almost half of the resected patients get recurrence in the liver. Methods: The ASAC trial is a Scandinavian, multicentre, double-blinded, randomized, placebo-controlled ...
    • Biliary Adenofibroma: A Rare Liver Tumor with Transition to Invasive Carcinoma 

      Alshbib, Ayham; Grzyb, Krzysztof; Syversveen, Trygve; Reims, Henrik Mikael; Lassen, Kristoffer; Yaqub, Sheraz (Journal article; Tidsskriftartikkel; Peer reviewed, 2022-02-07)
      Biliary adenofibroma is a rare benign liver tumor with potential for malignant transition. It has a bile duct origin characterized by a complex tubulocystic biliary epithelium with fibrous stroma. MRI features may suggest this uncommon entity, and histological findings can be diagnostic. We report a case of biliary adenofibroma with transformation to an intrahepatic cholangiocarcinoma.
    • Gastro- or Duodenojejunostomy Leaks After Pancreatoduodenectomy: Single Center Experience and Narrative Literature Review 

      Labori, Knut Jørgen; Tholfsen, Tore; Yaqub, Sheraz; Lassen, Kristoffer; Kleive, Dyre; Waage, Anne (Journal article; Tidsskriftartikkel; Peer reviewed, 2021-06-15)
      <i>Background and Methods</i> - Gastro- or duodenojejunostomy leaks after pancreatoduodenectomy is rare. This study aims to analyze the incidence, management, and outcome of gastro- or duodenojejunostomy leaks after pancreatoduodenectomy based on a single center experience from 2004 to 2020 with a narrative literature review.<br><br> <i>Results</i> - Of a total of 1494 pancreatoduodenectomies, ...
    • Laparoscopic versus open liver resection for intrahepatic cholangiocarcinoma: a multicenter propensity score-matched study 

      Sahakyan, Mushegh; Aghayan, Davit; Edwin, Bjørn von Gohren; Alikhanov, Ruslan; Britskaia, Natalia; Brudvik, Kristoffer Watten; D’Hondt, Mathieu; De Meyere, Celine; Efanov, Mikhail; Fretland, Åsmund Avdem; Hoff, Rune; Ismail, Warsan; Ivanecz, Arpad; Kazaryan, Airazat; Lassen, Kristoffer; Magdalenić, Tomislav; Parmentier, Isabelle; Røsok, Bård Ingvald; Villanger, Olaug; Yaqub, Sheraz (Journal article; Tidsskriftartikkel; Peer reviewed, 2022-11-14)
      Background: The role of laparoscopy in the treatment of intrahepatic cholangiocarcinoma (ICC) remains unclear. This multicenter study examined the outcomes of laparoscopic liver resection for ICC.<p> <p>Methods: Patients with ICC who had undergone laparoscopic or open liver resection between 2012 and 2019 at four European expert centers were included in the study. Laparoscopic and open approaches ...
    • Low Concordance Between T-Cell Densities in Matched Primary Tumors and Liver Metastases in Microsatellite Stable Colorectal Cancer 

      Johansen Dagenborg, Vegard; Marshall, Serena Elizabeth; Grzyb, Krzyzstof; Fretland, Åsmund Avdem; Lund-Iversen, Marius; Mælandsmo, Gunhild Mari; Hansen Ree, Anne; Edwin, Bjørn; Yaqub, Sheraz; Flatmark, Kjersti (Journal article; Tidsskriftartikkel; Peer reviewed, 2021-06-09)
      Background: The subtype, density and location of tumor infiltrating T-cells are being explored as prognostic and predictive biomarkers in primary colorectal cancer (pCRC) and colorectal liver metastases (CLM). Very limited data exist comparing findings in pCRC and matched CLM.<p> <p>Patients and methods: Fifty-eight patients with available pCRC and matched CLM (57/58 microsatellite stable) were ...
    • Simultaneous Resection of Primary Colorectal Cancer and Synchronous Liver Metastases: Contemporary Practice, Evidence and Knowledge Gaps 

      Kleive, Dyre; Aas, Eline; Bringeland, Erling Audun; Nesbakken, Arild; Nymo, Linn Såve; Schultz, Johannes Kurt; Søreide, Kjetil; Yaqub, Sheraz (Journal article; Tidsskriftartikkel; Peer reviewed, 2021-03-23)
      The timing of surgical resection of synchronous liver metastases from colorectal cancer has been debated for decades. Several strategies have been proposed, but high-level evidence remains scarce. Simultaneous resection of the primary tumour and liver metastases has been described in numerous retrospective audits and meta-analyses. The potential benefits of simultaneous resections are the eradication ...